ADC changes in schizophrenia: a diffusion-weighted imaging study

作者：Nenadic Igor^*; Wagner Gerd; Guellmar Daniel; Schachtzabel Claudia; von Con**ruch Katrin; Koehler Sabine; Koch Kathrin; Roebel Martin; Schultz C Christoph; Reichenbach Juergen R; Sauer Heinrich; Schloesser Ralf G M

来源：European Archives of Psychiatry and Clinical Neuroscience, 2011, 261(3): 213-216.

DOI：10.1007/s00406-010-0150-x

• Schizophrenia
• Brain
• Magnetic resonance imaging (MRI)
• Diffusion tensor imaging (DTI)
• Apparent diffusion coefficient (ADC)

Studies using diffusion tensor imaging (DTI) have shown multifocal reduction in anisotropy of white matter fibre tracts in schizophrenia, and a few of these also suggest changes in apparent diffusion coefficient (ADC). In this study, we assessed ADC in 18 patients with schizophrenia and 18 healthy controls using a voxel-based approach. We did not find evidence of statistically significant changes in ADC in either direction at P < 0.05 (FDR corrected) using different smoothing filter sizes; only at an uncorrected threshold of P < 0.001 did we find an increase in a small right prefrontal area close to our previous FA finding. Our findings therefore do not support ADC changes to be a marker of white matter or grey matter abnormalities in schizophrenia. Changes in other parameters like fractional anisotropy (FA) might be a more sensitive indicator of white matter pathology in this disorder.

• 出版日期2011-4