Phactr2 and Parkinson's disease

作者：Wider Christian; Lincoln Sarah J; Heckman Michael G; Diehl Nancy N; Stone Jeremy T; Haugrarvoll Kristoffer; Aasly Jan O; Gibson J Mark; Lynch Timothy; Rajput Alex; Rajput Michele L; Uitti Ryan J; Wszolek Zbigniew K; Farrer Matthew J; Ross Owen A^*

来源：Neuroscience Letters, 2009, 453(1): 9-11.

DOI：10.1016/j.neulet.2009.02.009

• Genome-wide association
• Parkinson's disease
• Phactr2

Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P = 0.032), Canadian (OR: 1.41, P = 0.014) and Irish (OR: 1.44, P = 0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P = 0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P < 0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.

• 出版日期2009-3-27