Adenosine A(3) receptors regulate heart rate, motor activity and body temperature

作者：Yang, J. N.; Wang, Y.; Garcia-Roves, P. M.; Bjornholm, M.; Fredholm, B. B.^*

来源：Acta Physiologica, 2010, 199(2): 221-230.

DOI：10.1111/j.1748-1716.2010.02091.x

• body weight
• diurnal
• heat production
• knock-out
• sex differences

Aim:
To examine the phenotype of mice that lack the adenosine A(3) receptor (A(3)R).
Methods:
We examined the heart rate, body temperature and locomotion continuously by telemetry over several days. In addition, the effect of the adenosine analogue R-N6-phenylisopropyl-adenosine (R-PIA) was examined. We also examined heat production and food intake.
Results:
We found that the marked diurnal variation in activity, heart rate and body temperature, with markedly higher values at night than during day time, was reduced in the A(3)R knock-out mice. Surprisingly, the reduction in heart rate, activity and body temperature seen after injection of R-PIA in wild type mice was virtually eliminated in the A(3)R knock-out mice. The marked reduction in activity was associated with a decreased heat production, as expected. However, the A(3)R knock-out mice, surprisingly, had a higher food intake but no difference in body weight compared to wild type mice.
Conclusions:
The mice lacking adenosine A(3) receptors exhibit a surprisingly clear phenotype with changes in diurnal rhythm and temperature regulation. Whether these effects are due to a physiological role of A(3) receptors in these processes or whether they represent a role in development remains to be elucidated.

• 出版日期2010-6
• 单位吉林大学