APOA5-1131T > C genotype effects on apolipoprotein A5 and triglyceride levels in response to dietary intervention and regular exercise (DIRE) in hypertriglyceridemic subjects

作者：Jang Yangsoo; Chae Jey Sook; Kim Oh Yoen; Park Hey Jun; Kim Ji Young; Paik Jean Kyung; Lee Sang Hyun; Lee Jong Ho^*

来源：Atherosclerosis, 2010, 211(2): 512-519.

DOI：10.1016/j.atherosclerosis.2010.03.014

• APOA5-1131 T > C
• Dietary intervention and regular exercise
• Triglycerides
• Hypertriglyceridemia
• Apolipoprotein A5

Objective: We aimed to determine the influence of apolipoprotein A5 gene (APOA5)-1131T>C single nucleotide polymorphism on the effects of dietary intervention and regular exercise (DIRE) targeting ApoA5 and triglyceride (TG) concentrations.
Methods: Hypertriglyceridemia patients (TG, 150-500 mg/dL, n = 283) undertook a 12-week DIRE (replacing 1/3 of refined rice in their diets with legumes, increasing vegetable intake, and regular walking).
Results: Pre-treatment, no genotype-related differences were detected in ApoA5, TG, or HDL cholesterol levels; however, post-treatment, subjects homozygous (T/T) for the T allele had lower serum TG(P = 0.009) and higher HDL cholesterol (P = 0.036) than other subjects. In T/T subjects, after adjustments for age, sex and weight changes (r1) or initial TG levels (r2), changes in ApoA5 levels negatively correlated with TG changes (r1= -0.29, P = 0.05, r2= -0.28, P < 0.1) and positively correlated with changes in HDL cholesterol (r1 = 0.30, P < 0.05, r2 = 0.32, P < 0.05) and free fatty acid (r1 = 0.38, P < 0.01, r2 = 0.40, P < 0.01). In those with moderate hypertriglyceridemia (TG, 200-500 mg/dL, n = 130), APOA5-1131T/T carriers achieved significantly lower TG (P = 0.007) and higher HDL cholesterol (P < 0.001) than -1131C allele carriers. Additionally, statistically significant interactions between the -1131T> C and the compliance of DIRE were found for the change in TG (P = 0.002) and HDL cholesterol (P = 0.039). In good compliance group, T/T subjects showed greater reduction of TG and higher increase of HDL cholesterol than other subjects. On the other hand, non-good compliance group had no significant improvement in these variables.
Conclusions: APOA5-1131T/T carriers may benefit more from the DIRE than C allele carriers. These effects were remarkable in patients with moderate hypertriglyceridemia and the individuals with good compliance.

• 出版日期2010-8