Assessment of human sinus cavity air volume using tunable diode laser spectroscopy, with application to sinusitis diagnostics

作者：Huang, Jing; Zhang, Hao; Li, Tianqi; Lin, Huiying; Svanberg, Katarina; Svanberg, Sune^*

来源：Journal of Biophotonics, 2015, 8(11-12): 985-992.

DOI：10.1002/jbio.201500110

• paranasal cavities
• frontal sinus
• GASMAS
• water vapor
• sinusitis
• antibiotic resistance

Sinusitis is a very common disease and improved diagnostic tools are desirable also in view of reducing over-prescription of antibiotics. A non-intrusive optical technique called GASMAS (GAs in Scattering Media Absorption Spectroscopy), which has a true potential of being developed into an important complement to other means of detection, was utilized in this work. Water vapor in the frontal sinuses, related to the free gas volume, was studied at around 937 nm in healthy volunteers. The results show a good stability of the GASMAS signals over extended times for the frontal sinuses for all volunteers, showing promising applicability to detect anomalies due to sinusitis. Measurements were also performed following the application of a decongestion spray. No noticeable signal change was observed, which is consistent with the fact that the water vapor concentration is given by the temperature only, and is not influenced by changes in cavity ventilation.

• 出版日期2015-11
• 单位华南师范大学