Applications of stem cell-derived exosomes in tissue engineering and neurological diseases

作者：Sun, Baichuan; Peng, Jiang; Wang, Shoufeng; Liu, Xuejian; Zhang, Kaihong; Zhang, Zengzeng; Wang, Chong; Jing, Xiaoguang; Zhou, Chengfu^*; Wang, Yu^*

来源：Reviews in the Neurosciences, 2018, 29(5): 531-546.

DOI：10.1515/revneuro-2017-0059

• exosomes
• extracellular vesicle
• intercellular communication
• neurological diseases
• stem cell
• tissue engineering

Exosomes are extracellular vesicles with diameters of 30-100 nm that are key for intercellular communication. Almost all types of cell, including dendritic cells, T cells, mast cells, epithelial cells, neuronal cells, adipocytes, mesenchymal stem cells, and platelets, can release exosomes. Exosomes are present in human body fluids, such as urine, amniotic fluid, malignant ascites, synovial fluid, breast milk, cerebrospinal fluid, semen, saliva, and blood. Exosomes have biological functions in immune response, antigen presentation, intercellular communication, and RNA and protein transfer. This review provides a brief overview of the origin, morphological characteristics, enrichment and identification methods, biological functions, and applications in tissue engineering and neurological diseases of exosomes.

• 出版日期2018-7
• 单位佳木斯大学; 中国人民解放军总医院; 南通大学