Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics

作者：Liao Yi Chu; Lin Hsiu Fen; Rundek Tanja; Cheng Rong; Hsi Edward; Sacco Ralph L; Juo Suh Hang Hank^*

来源：Clinical Biochemistry, 2008, 41(4-5): 306-312.

DOI：10.1016/j.clinbiochem.2007.11.011

• gene
• single nucleotide polymorphisms
• reverses cholesterol transport pathway
• lipids
• haplotype

Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics.
Design and methods: A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-Q, triglyceride (TG) and total cholesterol (TC).
Results: We identified 19 SNPs at 10 genes that were significantly related to lipids (p<0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7Al genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively.
Conclusions: The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.

• 出版日期2008-3
• 单位河北医科大学