Average Adherence to Boosted Protease Inhibitor Therapy, rather than the Pattern of Missed Doses, as a Predictor of HIV RNA Replication

作者：Parienti Jean Jacques^*; Ragland Kathleen; Lucht Frederic; de la Blanchardiere Arnaud; Dargere Sylvie; Yazdanpanah Yazdan; Dutheil Jean Jacques; Perre Philippe; Verdon Renaud; Bang**erg David R

来源：Clinical Infectious Diseases, 2010, 50(8): 1192-1197.

DOI：10.1086/651419

Consecutive missed doses may differentially impact the efficacy of antiretroviral therapy associated with the use of a nonnucleoside reverse-transcriptase inhibitor (NNRTI) and a ritonavir-boosted protease inhibitor (PI). In a cohort of 72 subjects receiving a boosted PI, average adherence to dosage was a better predictor of human immunodeficiency virus (HIV) replication than was the duration or frequency of treatment interruption. In contrast with an NNRTI, consecutive missed doses of a boosted PI did not emerge as a major risk factor for HIV replication.

• 出版日期2010-4-15