Astrotricoumarin, an antiproliferative 4 '-hydroxy-2 ',3 '-dihydroprenylated methylcoumarin from an Astrotrichilia sp. from the Madagascar dry forest[1]

作者：Harinantenaina Liva; Brodie Peggy J; Callmander Martin W; Randrianaivo Richard; Rakotonandrasana Stephan; Rasamison Vincent E; Rakotobe Etienne; Kingston David G I^*

来源：Natural Product Communications, 2011, 6(9): 1259-1262.

• Meliaceae
• dihydroprenyl methylcoumarin
• astrotricoumarin
• antiproliferative
• A2780

Bioassay guided fractionation of the ethanol extract of a new endemic species of the genus Astrotrichilia led to the isolation of the new antiproliferative 3-(4'-hydroxy-2',3'-dihydroprenyl)-4,6-dimethoxy-5-methylcoumarin, named astrotricoumarin (8) with an IC(50) value of 6.8 mu M against the A2780 cell line. The structure of compound 8 was elucidated on the basis of its physical and spectroscopic data, including extensive 1D- and 2D-NMR analysis.

• 出版日期2011-9
• 单位Virginia Tech; 美国弗吉尼亚理工大学(Virginia Tech)