Antiproliferative Effect from Sesquiterpene Lactones of Carpesium rosulatum MlQ Consumed in South Korea on the Five Human Cancer Cell Lines

作者：Moon Hyung In^*; Zee Okpyo

来源：Records of Natural Products, 2010, 4(3): 149-155.

• Carpesium rosulatum
• Cytotoxic activity
• human tumor cell lines
• SRB

In search for antiproliferative compound against human cancer cells (A549, SK-OV-3, SK-MEL- 2, XF498, HCT15), a chloroform soluble extract obtained by re-extraction of the methanol extract of whole plant of Carpesium rosulatum MlQ. (Compositae) exhibited cytotoxic activity. Four germacrane sesquiterpene lactones 2 alpha,5-epoxy-5,10-dihydroxy-6-angeloyl-oxy-9 beta-isobutyloxy-germacran-8 alpha,12-olide, 2 alpha,5-epoxy-5,10-dihydroxy-6 alpha,9 beta-diangeloyloxy-germacran-8 alpha,12-olide, 2 alpha,5-epoxy-5,10-dihydroxy-6 alpha-angeloyloxy- 9 beta-(3-methyl-butanoyloxy)-germacran-8 alpha,12-olide, and 2 beta,5-epoxy-5,10-dihydroxy-6 alpha,9 beta-diangeloyloxy- germacran-8 alpha,12-olide were isolated from the chloroform extract of C. rosulatum, and 2 alpha,5-epoxy- 5,10-dihydroxy-6 alpha,9 beta-diangeloyloxy-germacran-8 alpha,12-olide showed the most potent cytotoxicity with IC(50) value of 6.01 mu M against SK-MEL-2.

• 出版日期2010