Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum

作者：Tang, Jian; Li, Hui-Liang^*; Shen, Yun-Heng; Jin, Hui-Zi; Yan, Shi-Kai; Liu, Run-Hui; Zhang, Wei-Dong

来源：Phytotherapy Research, 2008, 22(8): 1093-1096.

DOI：10.1002/ptr.2463

• Veratrum dahuricum
• cyclopamine
• germine
• antitumor activity

The antitumor activity of six extracts (ethanol extract, petroleum ether fraction, CHCl3 fraction, ethyl acetate fraction, n-butanol fraction and total alkaloids) from the rhizomes of Veratrum dahuricum, and six compounds (veratramine (1), jervine (2), germine (3), veramitaline (4), veratrosine (5) and cyclopamine (6)) from the ethanol extract were investigated in vitro. The 12 samples exhibited cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249. Among these samples, CHCl3 fraction, the total alkaloids, compounds 1 and 6 showed higher inhibitory activity, compound 3 selectively exhibited significant cytotoxicity to SW1990 and NCI-H249.

• 出版日期2008-8
• 单位中国人民解放军第二军医大学; 上海交通大学