Direct synthesis of magnetite nanoparticles from iron(II) carboxymethylcellulose and their performance as NMR contrast agents

作者：da Silva Delmarcio Gomes; Toma Sergio Hiroshi; de Melo Fernando Menegatti; Carvalho Larissa Vieira C; Magalhaes Alvicler; Sabadini Edvaldo; dos Santos Antonio Domingues; Araki Koiti; Toma Henrique E^*

来源：Journal of Magnetism and Magnetic Materials, 2016, 397: 28-32.

DOI：10.1016/j.jmmm.2015.08.092

• NMR imaging
• Contrast agents
• Superparamagnetic nanoparticies
• Carboxymethylcelulose
• Relaxation time

Iron(II) carboxymethylcellulose (CMC) has been successfully employed in the synthesis of hydrophylic magnetite nanoparticles stabilized with a biopolymer coating, aiming applications in NMR imaging. The new method encompasses a convenient one-step synthetic procedure, allowing a good size control and yielding particles of about 10 nm (core size). In addition to the biocompatibility, the nanoparticles have promoted a drastic reduction in the transverse relaxation time (T-2) of the water protons. The relaxivity rates have been investigated as a function of the nanoparticles concentration, showing a better performance in relation to the common NMR contrast agents available in the market.

• 出版日期2016-1-1