A new acetophenone glycoside from the flower buds of Syzygium aromaticum (cloves)

作者：Ryu Byeol; Kim Hye Mi; Woo Jeong Hwa; Choi Jung Hye; Jang Dae Sik^*

来源：Fitoterapia, 2016, 115: 46-51.

DOI：10.1016/j.fitote.2016.09.021

• Syzygium aromaticum
• Cloves
• Myrtaceae
• Acetophenone
• Cytotoxicity
• Ovarian cancer cell

A new acetophenone, 2,4,6-trihydroxy-3-methylacetophenone-2-O-beta-D-glucoside (1), together with 21 known compounds; one acetophenone (2), four chromone glycosides (3-6), six phenylpropanoids (7-12), six sesquiterpenoids (13-18), two triterpenoids (19 and 20), one sterol (21), and one tannin (22) were isolated from the flower buds of Syzygium aromaticum (cloves). The structure of the new compound 1 was determined by spectroscopic analyses including 1D-, 2D-NMR and HRMS interpretation. Among the isolates, one acetophenone (2), three phenylpropanoids (10 - 12), and one sesquiterpenoid (13) were isolated from the flower buds of S. aromaticum for the first time in this study. All the isolates (1 - 22) were evaluated for their cytotoxicity against human ovarian cancer cells (A2780) using MU assays. Some of the isolates (5, 6, 9, 15, 17, 19, 20, and 21) showed either moderate or weak cytotoxidty on A2780 cells.

• 出版日期2016-12