Fe3O4 Nanoparticles as an Efficient and Magnetically Recoverable Catalyst for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones under Solvent-Free Conditions

作者：Nasr Esfahani Masoud^*; Hoseini S Jafar; Mohammadi Fatemeh

来源：Chinese Journal of Catalysis, 2011, 32(9): 1484-1489.

DOI：10.1016/S1872-2067(10)60263-X

• dihydropyrimidinones
• dihydropyrimidinthiones
• ferroferric oxide nanoparticle
• one-pot condensation
• solvent-free

The catalytic activity of Fe3O4 nanoparticles (NPs) in a one-pot three component condensation reaction consisting of an aromatic aldehyde, urea or thiourea, and a beta-dicarbonyl under solvent-free conditions was investigated. This reaction affords the corresponding dihydropyrimidinones (thiones) in high to excellent yields. Compared with the classical Biginelli reactions this method consistently gives a high yield, easy magnetic separation, a short reaction time, and catalyst reusability.

• 出版日期2011-9