Nitroxidative Signaling Mechanisms in Pathological Pain

作者：Grace Peter M; Gaudet Andrew D; Staikopoulos Vasiliki; Maier Steven F; Hutchinson Mark R; Salvemini Daniela; Watkins Linda R

来源：Trends in Neurosciences, 2016, 39(12): 862-879.

DOI：10.1016/j.tins.2016.10.003

Tissue injury can initiate bidirectional signaling between neurons, glia, and immune cells that creates and amplifies pain. While the ability for neurotransmitters, neuropeptides, and cytokines to initiate and maintain pain has been extensively studied, recent work has identified a key role for reactive oxygen and nitrogen species (ROS/RNS; nitroxidative species), including superoxide, peroxynitrite, and hydrogen peroxide. In this review we describe how nitroxidative species are generated after tissue injury and the mechanisms by which they enhance neuroexcitability in pain pathways. Finally, we discuss potential therapeutic strategies for normalizing nitroxidative signaling, which may also enhance opioid analgesia, to help to alleviate the enormous burden of pathological pain.

• 出版日期2016-12