Anti-inflammatory effect of quetiapine on collagen-induced arthritis of mouse

作者：Kim Hyeongseok; Bang Jihye; Chang Hyuk Won; Kim Jin Young; Park Keon Uk; Kim Sang Hyon; Lee Kyung Jae; Cho Chul Hyun; Hwang Ilseon; Park Sung Dong; Ha Eunyoung^*; Jung Sung Won

来源：European Journal of Pharmacology, 2012, 678(1-3): 55-60.

DOI：10.1016/j.ejphar.2011.12.017

• Quetiapine
• Inflammation
• IL-17 (interleukin-17)
• IL-6 (interleukin-6)
• Rheumatoid arthritis

Quetiapine is an atypical antipsychotic and has also been used in the treatment of depression. Since anti-inflammatory effects of antidepressants are well established, we hypothesized that quetiapine may also exert anti-inflammatory effects. Thus this study was designed to examine the anti-inflammatory effect of quetiapine in murine collagen-induced arthritis. Mice were immunized with collagen type II for the induction of arthritis and treated with quetiapine (10 mg/kg) daily for 2 weeks. Mice were divided into 3 groups: control, CIA, and CIA + quetiapine treatment. Arthritic index and paw thickness were used to compare severity of arthritis. In additions, radiological and histological assessments were employed. Anti-type II collagen-specific antibody, interleukin-6 (IL-6), interleukin-17 (IL-17), and prostaglandin E-2 (PGE(2)) were evaluated at the end of the treatment period. Both arthritic index and paw thickness were markedly improved in CIA+quetiapine treatment group compared with those in CIA groups (arthritic index; P%26lt;0.01, paw thickness; P%26lt;0.05). Radiologic assessment revealed decreased cartilage damage and bone erosion in CIA+quetiapine treatment group compared with those in CIA groups. Articular cartilage destruction observed in CIA group was not found in CIA+quetiapine group. The concentrations of anti-type II collagen-specific antibody, IL-6, IL-17, and PGE(2) in CIA+quetiapine group were significantly lower than those in CIA groups (P%26lt;0.05). Weight gain which is commonly observed with the treatment of antipsychotics was not observed. Taken together, these results suggest that quetiapine shows anti-inflammatory effects inmurine collagen-induced arthritis.

• 出版日期2012-3-5