A Membrane Lung Design Based on Circular Blood Flow Paths

作者：Fernando Uditha Piyumindri; Thompson Alex J; Potkay Joseph; Cheriyan Hannah; Toomasian John; Kaesler Andreas; Schlanstein Peter; Arens Jutta; Hirschl Ronald B; Bull Joseph L; Bartlett Robert H^*

来源：ASAIO Journal, 2017, 63(5): 637-643.

DOI：10.1097/MAT.0000000000000616

• artificial lung
• circular flow
• mixing
• oxygenation

Current hollow fiber membrane lungs feature a predominantly straight blood path length across the fiber bundle, resulting in limited O-2 transfer efficiency because of the diffusion boundary layer effect. Using computational fluid dynamics and optical flow visualization methods, a hollow fiber membrane lung was designed comprising unique concentric circular blood flow paths connected by gates. The prototype lung, comprising a fiber surface area of 0.28 m(2), has a rated flow of 2 L/min, and the oxygenation efficiency is 357 ml/min/m(2). The CO2 clearance of the lung is 200 ml/min at the rated blood flow. Given its high gas transfer efficiency, as well as its compact size, low priming volume, and propensity for minimal thrombogenicity, this lung design has the potential to be used in a range of acute and chronic respiratory support applications, including providing total respiratory support for infants and small children and CO2 clearance in adults.

• 出版日期2017-10