ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

作者：Dijk Wieneke; Heine Markus; Vergnes Laurent; Boon Mariette R; Schaart Gert; Hesselink Matthijs K C; Reue Karen; Lichtenbelt Wouter D van Marken; Olivecrona Gunilla; Rensen Patrick C N; Heeren Joerg; Kersten Sander^*

来源：eLife, 2015, 4: e08428.

DOI：10.7554/eLife.08428

Brown adipose tissue (BAT) activation via cold exposure is increasingly scrutinized as a potential approach to ameliorate cardio-metabolic risk. Transition to cold temperatures requires changes in the partitioning of energy substrates, re-routing fatty acids to BAT to fuel non-shivering thermogenesis. However, the mechanisms behind the redistribution of energy substrates to BAT remain largely unknown. Angiopoietin-like 4 (ANGPTL4), a protein that inhibits lipoprotein lipase (LPL) activity, is highly expressed in BAT. Here, we demonstrate that ANGPTL4 is part of a shuttling mechanism that directs fatty acids derived from circulating triglyceride-rich lipoproteins to BAT during cold. Specifically, we show that cold markedly down-regulates ANGPTL4 in BAT, likely via activation of AMPK, enhancing LPL activity and uptake of plasma triglyceride-derived fatty acids. In contrast, cold up-regulates ANGPTL4 in WAT, abolishing a cold-induced increase in LPL activity. Together, our data indicate that ANGPTL4 is an important regulator of plasma lipid partitioning during sustained cold. DOI:10.7554/eLife.08428.001

• 出版日期2015-10-17