N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study

作者：Wu, Jian^*; Kang, Shenghong; Yuan, Qinkun; Luo, Lijun; Ma, Juan; Shi, Qingcai; Yang, Song

来源：Molecules, 2012, 17(8): 9413-9420.

DOI：10.3390/molecules17089413

• pridazin-3(2H)-one
• synthesis
• insecticidal activity
• SAR study
• Plutella xylostella

A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.

• 出版日期2012-8
• 单位贵州大学