科研之友
微信
新浪微博
Facebook
分享链接
摘要
The amination of benzylic and cinnamic alcohols was achieved via a biocatalytic, one-pot oxidation-transamination cascade in aqueous medium at physiological conditions. Alcohol oxidation by galactose oxidase at the expense of O-2 furnished the corresponding aldehydes, which were aminated using omega-transaminases in situ. The applicability of this method was demonstrated by a short synthesis of the antifungal agent naftifine.
- 出版日期2012
