Multicomponent Strategy to Pyrazolo[3,4-e]indolizine Derivatives under Microwave Irradiation

作者：Wang, Jian-Jun; Feng, Xian; Xun, Zhan; Shi, Da-Qing^*; Huang, Zhi-Bin

来源：Journal of Organic Chemistry, 2015, 80(16): 8435-8442.

DOI：10.1021/acs.joc.5b01314

• HIGHLY EFFICIENT SYNTHESIS
• SELECTIVE SYNTHESIS
• HYDROISOQUINOLINE DERIVATIVES
• CATALYZED CYCLOISOMERIZATION
• FUNCTIONALIZED INDOLIZINES
• CYCLOADDITION REACTIONS
• POTENT INHIBITORS
• N,S-KETENE ACETAL
• DOMINO REACTION
• PYRIDINIUM

A simple and efficient one-pot construction of pyrazolo[3,4-e]indolizine derivatives via a diethylamine-catalyzed three-component domino reaction of arylglyoxals, cyclic 1,3-diones, and 5-aminopyrazoles under microwave irradiation is described. In this one-pot transformation, seven bonds and two new rings are efficiently formed. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional recrystallization or chromatography purification methods.

• 出版日期2015-8-21
• 单位苏州大学