摘要

A new intramolecular charge transfer (ICT) based colorimetric and ratiometric fluorescent chemodosimeter for the detection of Hg2+ has been rationally designed and developed. The probe operates via the specific mercury-promoted desulfurization reaction of thiocoumarin to coumarin and exhibits high selectivity and sensitivity in almost pure aqueous solution (containing only 1% DMSO) with a Low detection Limit of 1.85 ppb. Furthermore, the probe was successfully used for the fluorescence imaging of Hg2+ in Live cells.