Antibodies to myelin basic protein are associated with cognitive decline after stroke

作者：Becker Kyra J^*; Tanzi Patricia; Zierath Dannielle; Buckwalter Marion S

来源：Journal of Neuroimmunology, 2016, 295: 9-11.

DOI：10.1016/j.jneuroim.2016.04.001

• Stroke
• Cognitive decline
• Autoimmune
• MBP antibodies

B lymphocytes cause post-stroke cognitive decline in mice. We therefore evaluated the association between autoantibodies and post-stroke cognitive decline in a prospectively collected human cohort. The mini-mental state exam (MMSE) was administered 30, 90, 180, and 365 days after stroke. Antibody titers to myelin basic protein (MBP), proteolipid protein, and several non-specific proteins were determined. Among 58 subjects with initial MMSE 20 and at least 2 MMSE examinations in the year after stroke, cognitive decline (MMSE decrease 2) occurred in 10 (17%) subjects. In multivariate analysis, MBP antibody titers were the only independent predictor of cognitive decline (OR = 9.02 [1.18, 68.90]; P = 0.03).

• 出版日期2016-6-15