MULTIMODAL TREATMENT OF PATIENTS WITH MINOR SALIVARY GLAND CANCER IN THE CASE OF RECURRENT DISEASE

作者：Erovic Boban M; Schopper Christian; Pammer Johannes; Vormittag Laurenz; Maleki Amir; Brunner Markus; Heiduschka Gregor; Grasl Matthaeus Ch; Thurnher Dietnnar^*

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2010, 32(9): 1167-1172.

DOI：10.1002/hed.21312

• salivary gland tumors
• recurrence
• treatment modalities

Background. Our aim in this study was to identify prognostic factors and the optimal therapeutic management in patients with minor salivary gland carcinomas.
Methods. Overall and disease-free survival and overall survival after recurrence in patients with adenoidcystic carcinoma (n = 25), mucoepidermoid carcinoma (n = 8), adenocarcinoma (n = 5), carcinoma ex pleomorphic adenoma (n = 4), and others (n = 5) were correlated to clinical data.
Results. Overall survival correlated to treatment modality (p = .039) and T classification (p = .003), whereas prolonged disease-free interval correlated to treatment (p < .001) and T classification (p = .009). Overall survival after recurrence correlated to treatment of recurrence (p = .006) and initial T classification (p = .02). Multivariate analysis showed that overall survival after recurrence correlated to treatment of recurrence (p = .019) and initial T classification (p = 0.019). T classification was a prognostic factor for overall survival (p = .002) and disease-free interval (p = .002).
Conclusions. The initial tumor classification is a clinical predictor for patients' overall and disease-free survival and overall survival after recurrence. Multimodal treatment significantly improves patients' overall survival.

• 出版日期2010-9