Acute cardiac dysfunction after short-term diesel exhaust particles exposure

作者：Huang Chien Hua; Lin Lian Yu; Tsai Min Shan; Hsu Chiung Yuan; Chen Huei Wen; Wang Tzung Dau; Chang Wei Tien; Cheng Tsun Jen; Chen Wen Jone^*

来源：Toxicology Letters, 2010, 192(3): 349-355.

DOI：10.1016/j.toxlet.2009.11.008

• Diesel exhaust particles
• Cardiac function
• Cytokines
• Heart rate variability
• Rats

Epidemiological studies show an association between particulate matter exposure and acute heart failure However, underlying mechanisms remain unclear. In this study, we investigated acute cardiac hemodynamic effects and related mechanisms after 1 day exposure to diesel exhaust particles (DEPs) Male Sprague-Dawley rats were randomized and instilled with 250 mu g (low dose) or 500 mu g (high dose) of DEP or saline placebo intra-tracheally The cardiac systolic function by dP/dt(40) and diastolic functions by maximal negative dP/dt were both worse in DEP low dose and DEP high dose groups than the control group, respectively. In the heart rate variability analysis. SDNN in DEP low dose and DEP high dose groups were both lower than the control group The low frequency heart rate variability was higher in the DEP groups compared to the control group The cardiac IL-1 beta expression and circulating cardiac troponin I level were higher in the DEP group than the control group Plasma IL-1 beta and IL-6 protein were significantly higher in the DEP groups than the control group In conclusion, DEP exposure causes acute cardiac systolic and diastolic dysfunction. The changes may be related to decreased heart rate variability, increased cardiac inflammatory reaction and myocardial damage.

• 出版日期2010-2-15