Aza-Michael Addition Reactions of Hydrazones with Activated Alkynes Catalyzed by Nitrogen-Containing Organic Bases

作者：Yuan, Zhi-Liang; Wei, Yin; Shi, Min^*

来源：European Journal of Organic Chemistry, 2010, (21): 4088-4097.

DOI：10.1002/ejoc.201000365

• Organocatalysis
• Michael addition
• Hydrazones
• Alkynes

Several highly efficient DABCO (1,4-diazabicyclo[2.2.2]-octane)-catalyzed Michael-type reactions of hydrazones with activated alkynes are described in this paper. This aza-Michael addition reaction can be applied to different types of hydrazones, such as hydrazones 1 and hydroxy-bearing hydrazones 5. The corresponding adducts are achieved in high yields under mild reaction conditions. DABCO-promoted aza-Michael addition reactions were successfully applied to a serious of hydrazones with activated alkynes to afford the corresponding adducts in moderate to good yields.

• 出版日期2010-7
• 单位中国科学院; 金属有机化学国家重点实验室