An efficient intermolecular [Pd]-catalyzed C-C and intramolecular [Cu]-catalyzed C-O bonds formation: synthesis of functionalized flavans and benzoxepine

作者：Suchand B; Krishna J; Ramulu B Venkat; Dibyendu D; Reddy A Gopi Krishna; Mahendar L; Satyanarayana G^*

来源：Tetrahedron Letters, 2012, 53(30): 3861-3864.

DOI：10.1016/j.tetlet.2012.05.050

• Flavans
• [Pd]-catalysis
• [Cu]-catalysis
• Dihydrochalcones
• Secondary alcohols

An efficient three-step strategy for the synthesis of functionalized flavans, starting from readily available 2-bromoiodobenzenes and aryl vinyl alcohols, is presented and successfully extended to benzoxepine. An intermolecular [Pd]-catalyzed C-C and an intramolecular [Cu]-catalyzed C-O bond formations have been employed as key transformations of the strategy.

• 出版日期2012-7-25