A 'click chemistry' approach to the straightforward synthesis of new 4-aryl-1,2,3-triazolocarbanucleosides

作者：Perez Castro Isabel; Caamano Olga; Fernandez Franco^*; Garcia Marcos D; Lopez Carmen; de Clercq Erik

来源：ARKIVOC, 2010, 152-168.

• Click chemistry
• triazoles
• carbanucleosides
• antiviral
• ribavirin

The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolyl carbanucleosides of type (+/-)-10/(+/-)-11 related to the broad spectrum antiviral agent ribavirin 1 are described. These compounds were produced using a "click chemistry" strategy starting from readily available protected alcohol 13b. The synthetic approach made use of olefin-based organic reactions for the stereoselective construction of the appropriately functionalized cyclopentane ring moiety followed by copper (I) catalyzed Huisgen 1,3-dipolar cycloaddition of azides and alkynes for the regioselective construction of the heterocyclic triazole moiety.

• 出版日期2010
• 单位河北医科大学