Development and characterization of stable nanovesicular carrier for drug delivery

作者：Gaur Praveen Kumar^*; Purohit Suresh; Kumar Yatendra; Mishra Shikha; Bhandari Anil

来源：Artificial Cells Nanomedicine and Biotechnology, 2014, 42(5): 296-301.

DOI：10.3109/21691401.2013.818009

• in vitro drug release
• polydispersity index
• stability
• vesicles

Lipid vesicles are an important drug carrier which can serve for controlled delivery of drugs; however, these vesicles are quite unstable at ambient temperature and require stringent storage condition.
Present work was done to develop a stable vesicular system for drug delivery. Vesicles of ceramide-2, cholesterol, cholesterol sulfate, and palmitic acid were prepared and compared with phosphatidylcholine vesicles for physicochemical parameters and accelerated stability. Diclofenac sodium was used as a model drug.
Based on physicochemical parameter and in vitro release PCV-3 and CV-3 were selected for further studies in three different accelerated stability conditions. PCV-3 showed moderate changes at 4 degrees C but was severely affected at 25 degrees C and 40 degrees C. CV-3 showed stable characteristics at 4 degrees C and 25 degrees C whereas at 40 degrees C, CV-3 showed signs of slight modification owing to moisture absorption.
Based on the study, CV-3 containing highest content of palmitic acid was found to be most stable.

• 出版日期2014-10