科研之友
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摘要
Members of the anti-apoptotic Bcl-2 family and AMBRA1 (activating molecule in beclin 1-regulated autophagy) interact with Beclin 1 and control autophagy. Bcl-2 is a negative regulator of autophagy whereas AMBRA1 stimulates autophagy. A paper in this issue of The EMBO Journal reveals an interaction between AMBRA1 and Bcl-2 at the mitochondrial outer membrane. In response to nutrient withdrawal, this interaction is dissociated, and AMBRA1 associates with Beclin 1 at the endoplasmic reticulum (ER) and mitochondria to stimulate autophagy. Bcl-2 can thus regulate the initiation of autophagy at the ER as well as at mitochondrial membranes. In addition, binding between AMBRA1 and mito-BCL-2 is reduced during apoptosis and this may enhance the anti-apoptotic functions of Bcl-2. This work provides important novel insight into the importance of subcellular location on the activity of autophagy proteins and the crosstalk between autophagy and apoptosis.
- 出版日期2011-4-6
