A novel semi-robotized device for high-precision F-18-FDG-guided breast cancer biopsy

作者:Hellingman D; Teixeira S C; Donswijk M L; Rijkhorst E J; Moliner L; Alamo J; Loo C E; Olmos R A Valdes*; Stokkel M P M
来源:Revista Espanola de Medicina Nuclear e Imagen Molecular, 2017, 36(3): 158-165.
DOI:10.1016/j.remn.2016.11.003

摘要

Purpose: To assess the 3D geometric sampling accuracy of a new PET-guided system for breast cancer biopsy (BCB) from areas within the tumour with high F-18-FDG uptake. Materials and methods: In the context of the European Union project MammoCare, a prototype semi robotic stereotactic prototype BCB-device was incorporated into a dedicated high resolution PET-detector for breast imaging. The system consists of 2 stacked rings, each containing 12 plane detectors, forming a dodecagon with a 186 mm aperture for 3D reconstruction (1 mm(3) voxel). A vacuum-assisted biopsy needle attached to a robot-controlled arm was used. To test the accuracy of needle placement, the needle tip was labelled with F-18-FDG and positioned at 78 target coordinates distributed over a 35 mm x 24 mm x 28 mm volume within the PET-detector field-of-view. At each position images were acquired from which the needle positioning accuracy was calculated. Additionally, phantom-based biopsy proofs, as as MammoCare images of 5 breast cancer patients, were evaluated for the 3D automated locating of F-18-FDG uptake areas within the tumour. Results: Needle positioning tests revealed an average accuracy of 0.5 mm (range 0-1 mm), 0.6 mm (range 0-2 mm), and 0.4 mm (range 0-2 mm) for the x/y/z-axes, respectively. Furthermore, the MammoCare system was able to visualize and locate small (<10 mm) regions with high F-18-FDG uptake within the tumour suitable for PET-guided biopsy after being located by the 3D automated application. Conclusions: Accuracy testing demonstrated high-precision of this semi-automatic 3D PET-guided system for breast cancer core needle biopsy. Its clinical feasibility evaluation in breast cancer patients scheduled for neo-adjuvant chemotherapy will follow.

  • 出版日期2017-6