Dengue viruses cluster antigenically but not as discrete serotypes

作者：Katzelnick Leah C; Fonville Judith M; Gromowski Gregory D; Arriaga Jose Bustos; Green Angela; James Sarah L; Lau Louis; Montoya Magelda; Wang Chunling; VanBlargan Laura A; Russell Colin A; Thu Hlaing Myat; Pierson Theodore C; Buchy Philippe; Aaskov John G; Munoz Jordan Jorge L; Vasilakis Nikos; Gibbons Robert V; Tesh Robert B; Osterhaus Albert D M E; Fouchier Ron A M; Durbin Anna; Simmons Cameron P; Holmes Edward C; Harris Eva; Whitehead Stephen S

来源：Science, 2015, 349(6254): 1338-1343.

DOI：10.1126/science.aac5017

The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution. We characterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.

• 出版日期2015-9-18
• 单位河北医科大学; NIH