Autoinflammatory Bone Diseases

作者：Stern Sara M^*; Ferguson Polly J

来源：Rheumatic Disease Clinics of North America, 2013, 39(4): 735-+.

DOI：10.1016/j.rdc.2013.05.002

• Chronic nonbacterial osteomyelitis
• Autoinflammatory bone diseases
• Majeed syndrome
• DIRA
• SAPHO syndrome
• CRMO
• Cherubism

Autoinflammatory bone disease is a new branch of autoinflammatory diseases caused by seemingly unprovoked activation of the innate immune system leading to an osseous inflammatory process. The inflammatory bone lesions in these disorders are characterized by chronic inflammation that is typically culture negative with no demonstrable organism on histopathology. The most common autoinflammatory bone diseases in childhood include chronic nonbacterial osteomyelitis (CNO), synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, Majeed syndrome, deficiency of interleukin-1 receptor antagonist, and cherubism. In this article, the authors focus on CNO and summarize the distinct genetic autoinflammatory bone syndromes.

• 出版日期2013-11