A mild and practical synthesis of biphenyl compounds

作者:Liang Shuang; Cao Xiaohui; Yan Xilong*; Chen Ligong
来源:Journal of Chemical Research, 2012, (9): 555-556.
DOI:10.3184/174751912X13419099572319

摘要

A mild and practical synthetic route for biphenyls is established. Isopropyl nitrite was prepared from sodium nitrite, isopropanol and hydrochloric acid. The biphenyl compounds were obtained from the diazotisation of aniline derivatives with the generated isopropyl nitrite and the coupling reaction with benzene derivatives in the presence of CuCl as a catalyst in good yields.