Leucoreduction of blood components: an effective way to increase blood safety?

作者：Bianchi Maria; Vaglio Stefania; Pupella Simonetta; Marano Giuseppe; Facco Giuseppina; Liumbruno Giancarlo M^*; Grazzini Giuliano

来源：Blood Transfusion, 2016, 14(3): 214-227.

DOI：10.2450/2015.0154-15

• blood component transfusion
• leucocyte reduction procedures
• leucocyte reduction filtration
• cost effectiveness
• transfusion reactions

Over the past 30 years, it has been demonstrated that removal of white blood cells from blood components is effective in preventing some adverse reactions such as febrile non-haemolytic transfusion reactions, immunisation against human leucocyte antigens and human platelet antigens, and transmission of cytomegalovirus. In this review we discuss indications for leucoreduction and classify them into three categories: evidence-based indications for which the clinical efficacy is proven, indications based on the analysis of observational clinical studies with very consistent results and indications for which the clinical efficacy is partial or unproven.

• 出版日期2016