Accurate particle size distribution determination by nanoparticle tracking analysis based on 2-D Brownian dynamics simulation

作者：Saveyn H; De Baets B; Thas O; Hole P; Smith J; Van der Meeren P^*

来源：Journal of Colloid and Interface Science, 2010, 352(2): 593-600.

DOI：10.1016/j.jcis.2010.09.006

• Particle size analysis
• Tracking
• Submicron
• Simulation
• Diffusion

A physical model is presented to simulate the average step length distribution during nanoparticle tracking analysis experiments as a function of the particle size distribution and the distribution of the number of steps within the tracks Considering only tracks of at least five steps numerical simulation could be replaced by a normal distribution approximation Based on this model simulation of a step length distribution allows obtaining a much more reliable estimation of the particle size distribution thereby reducing the artificial broadening of the distribution as is typically observed by direct conversion of step length to particle size data As this fitting procedure also allowed including data from particles that were fol lowed for a relatively low number of steps the measurement time could be reduced for particles that are known to be monodisperse Whereas the inversion is less sensitive towards the particle size distribution width still similar values were obtained for both th

• 出版日期2010-12-15