Phloroglucinol derivatives and a chromone glucoside from the leaves of Myrtus communis

作者：Tanaka Naonobu; Jia Yuyu; Niwa Kanji; Imabayashi Kiyoshi; Tatano Yutaka; Yagi Hideki; Kashiwada Yoshiki^*

来源：Tetrahedron, 2018, 74(1): 117-123.

DOI：10.1016/j.tet.2017.11.044

• Phloroglucinol derivative
• Myrtucommunin
• Myrtus communis
• Myrtaceae

Seven new phloroglucinol derivatives, myrtucommunins A D (1-4), 6-methylisomyrtucommulone B (5), 4-methylmyrtucommulone B (6), and 2-isobutyryl-4-methylphloroglucinol 1-O-beta-D-glucopyranoside (7), and one new chromone derivative, undulatoside A 6'-O-gallate (8), were isolated from the leaves of Myrtus communis (Myrtaceae). Myrtucommunins A D (1-4) were conjugates of polymethylated acylphloroglucinol and flavonol rhamnoside. The absolute configurations of the rhamnosyl moieties for 1-4 were confirmed to be L in each case by HPLC analyses, while those of the aglycones were assigned by comparisons of the experimental and TDDFI' calculated ECD spectra. 6-Methylisomyrtucommulone B (5) and 4-methylmyrtucommulone B (6) were assigned as 616/6 tricyclic acylphloroglucinol derivatives with a racemic nature. Antimicrobial activities of 1-8 and related known compounds were evaluated.

• 出版日期2018-1-4