An eye on RNAi in nematode parasites

作者：Maule Aaron G^*; McVeigh Paul; Dalzell Johnathan J; Atkinson Louise; Mousley Angela; Marks Nikki J

来源：Trends in Parasitology, 2011, 27(11): 505-513.

DOI：10.1016/j.pt.2011.07.004

RNA interference (RNAi) has revolutionised approaches to gene function determination. From a parasitology perspective, gene function studies have the added dimension of providing validation data, increasingly deemed essential to the initial phases of drug target selection, pre-screen development. Notionally advantageous to those working on nematode parasites is the fact that Caenorhabditis elegans research spawned RNAi discovery and continues to seed our understanding of its fundamentals. Unfortunately, RNAi data for nematode parasites illustrate variable and inconsistent susceptibilities which undermine confidence and exploitation. Now well-ensconced in an era of nematode parasite genomics, we can begin to unscramble this variation.

• 出版日期2011-11