Apelin and its receptor APJ in cardiovascular diseases

作者：Yu, Xiao Hua^*; Tang, Zhi Bin; Liu, Li Jing; Qian, Hong; Tang, Shi Lin; Zhang, Da Wei; Tian, Guo Ping; Tang, Chao Ke

来源：Clinica Chimica Acta, 2014, 428: 1-8.

DOI：10.1016/j.cca.2013.09.001

• Apelin
• APJ
• Atherosclerosis
• CAD
• Heart failure
• Hypertension

Apelin is an adipokine that has been identified as an endogenous ligand for the orphan receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular preponderance for the heart and vasculature. Apelin has powerful positive inotropic actions and causes endothelium- and nitric oxide-dependent vasodilatation. Growing evidence shows that apelin/APJ system functions as a critical mediator of cardiovascular homeostasis and is involved in the pathophysiology of cardiovascular diseases. Targeting apelin/APJ axis produces protection against cardiovascular diseases. In the current review we have summarized recent data concerning the role and therapeutic potential of apelin/APJ in several major cardiovascular diseases. An increased understanding of the cardiovascular actions of apelin/APJ system will help to develop novel therapeutic interventions for cardiovascular diseases.

• 出版日期2014-1-20
• 单位湖南医药学院; 南华大学