Discovery, absolute assignments, and total synthesis of asperversiamides A-C and their potent activity against Mycobacterium marinum

作者:Hou, Xue-Mei; Liang, Ting-Mei; Guo, Zhi-Yong; Wang, Chang-Yun; Shao, Chang-Lun*
来源:Chemical communications, 2019, 55(8): 1104-1107.
DOI:10.1039/c8cc09347d

摘要

Integrating molecular networking and H-1 NMR techniques successfully enabled the discovery of three new cycloheptapeptides, asperversiamides A-C (1-3). Their complete structures were further confirmed by total synthesis. All three compounds exhibited potent inhibitory activity against Mycobacterium marinum.