Ablation of Multiwavelet Re-entry Guided by Circuit-Density and Distribution Maximizing the Probability of Circuit Annihilation

作者：Carrick Richard T; Benson Bryce; Habel Nicole; Bates Oliver R J; Bates Jason H T; Spector Peter S^*

来源：Circulation-Arrhythmia and Electrophysiology, 2013, 6(6): 1229-1235.

DOI：10.1161/CIRCEP.113.000759

• arrhythmias
• cardiac
• atrial fibrillation
• catheter ablation
• electrophysiology

Background A key mechanism responsible for atrial fibrillation is multiwavelet re-entry (MWR). We have previously demonstrated improved efficiency of ablation when lesions were placed in regions of high circuit-density. In this study, we undertook a quantitative assessment of the relative effect of ablation on the probability of MWR termination and the inducibility of MWR, as a function of lesion length and circuit-density overlap. %26lt;br%26gt;Methods and Results We used a computational model to simulate MWR in tissues with (and without) localized regions of decreased action potential duration and increased intercellular resistance. We measured baseline circuit-density and distribution. We then assessed the effect of various ablation lesion sets on the inducibility and duration of MWR as a function of ablation lesion length and overlap with circuit-density. Higher circuit-density reproducibly localized to regions of shorter wavelength. Ablation lines with high circuit-density overlap showed maximum decreases in duration of MWR at lengths equal to the distance from the tissue boundary to the far side of the high circuit-density region (high-overlap, -43.5% [confidence interval, -22.0% to -65.1%] versus low-overlap, -4.4% [confidence interval, 7.3% to -16.0%]). Further ablation (beyond the length required to cross the high circuit-density region) provided minimal further reductions in duration and increased inducibility. %26lt;br%26gt;Conclusions Ablation at sites of high circuit-density most efficiently decreased re-entrant duration while minimally increasing inducibility. Ablation lines delivered at sites of low circuit-density minimally decreased duration yet increased inducibility of MWR.

• 出版日期2013-12