Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205

作者：Spasov A A; Kalitin K Yu^*; Grechko O Yu; Anisimova V A

来源：Bulletin of Experimental Biology and Medicine, 2016, 160(3): 336-339.

DOI：10.1007/s10517-016-3164-1

• kindling
• pentylenetetrazole
• antiepileptic activity
• anticonvulsant effect
• epilepsy

Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice. Sodium valproate was used as the reference substance. RU-1205 was superior to sodium valproate by anticonvulsant activity (by 12 times) and therapeutic index (by 8.5 times). In contrast to sodium valproate, RU-1205 exhibited significant anticonvulsant activity on the model of pentylenetetrazole-induced kindling without tendency to resistance development.

• 出版日期2016-1