An unprecedented Ag-pipemidic acid complex with helical structure: Synthesis, structure and interaction with CT-DNA

作者：Li Meng Ting; Sun Jing Wen; Sha Jing Quan^*; Wu Hong Bin; Zhang Er Lin; Zheng Tao Ye

来源：Journal of Molecular Structure, 2013, 1045: 29-34.

DOI：10.1016/j.molstruc.2013.04.028

• Pipemidic acid
• Silver
• Crystal structure
• Interaction with CT-DNA
• Helical structure

A new Ag-pipemidic acid complex with helical structure has been prepared and structurally characterized by routine technique. Single-crystal X-ray diffraction analysis shows that there are the left- and right-handed helical chains constructed by Ag ions and PPA drugs along the b direction. And two types of helical chains are connected into 2D layer by sharing pseudo-tetra-nuclear clusters, which are stabilized by PPA-1 molecules as scaffolds. UV study of the interaction of the complex with CT-DNA shows that the title complex can bind to the CT-DNA and exhibits the higher binding constant (K-b) than free HPPA drugs. Additionally, its competitive study with ethidium bromide and the relatively high K-SV value also indicates that complex can bind to DNA for the intercalative binding sites.

• 出版日期2013-8-6
• 单位佳木斯大学