An efficient one-pot biginelli condensation of aliphatic aldehydes catalyzed by zinc bromide under solvent-free conditions

作者：Yu Yang; Liu Di; Liu Chunsheng; Jiang Heng; Luo Genxiang^*

来源：Preparative Biochemistry & Biotechnology, 2007, 37(4): 381-387.

DOI：10.1080/10826060701593290

• zinc bromide
• catalyst
• aliphatic aldehydes
• Biginelli reaction
• dihydropyrimidinoes
• one-pot synthesis

Zinc bromide catalyzes the three component condensation reaction of an aldehyde, urea, and beta-ketoester or beta-diketone under solvent-free conditions to afford the corresponding dihydropyrimidinones ( DHPMs) with moderate to high yields in short reaction time. The present method is very effective for the Biginelli condensation of aliphatic aldehydes.

• 出版日期2007
• 单位辽宁石油化工大学