Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder

作者：Tzang Ruu Fen; Wang Ya Ching; Yeh Chin Bin; Hsu Cheng Dien; Liang Hsin Yi; Yang Pin Chen; Liu Hung Jen; Huang Yu Shu; Cheng Helen; Hsu Ya Chen; Liu Shen Ing; Pan Chia Ho; Huang Ya Fen; Huang Chi Fen; Wu Yu Yu; Huang Yu Hsin; Liu Hui Ching; Chang Hsueh Ling^*

来源：Psychiatry and Clinical Neurosciences, 2012, 66(1): 53-63.

DOI：10.1111/j.1440-1819.2011.02289.x

• attention-deficit-hyperactivity disorder
• functionality
• OROS-MPH
• recovery rate
• remission rate

Aim: To determine the differences in the remission rate, recovery rate, functional improvement, and treatment adherence related to treatment with short-acting immediate-release methylphenidate (IR-MPH) and long-acting osmotic-release oral system-methylphenidate (OROS-MPH) in a naturalistic setting among Taiwanese children with attention-deficithyperactivity disorder (ADHD). %26lt;br%26gt;Methods: A total of 757 children with ADHD, aged 6-18 years, was evaluated using the following in order determine functional improvement and treatment adherence: the Chinese version of the Swanson, Nolan, and Pelham, version IV scale (SNAP-IV-C), Clinical Global Impression-ADHD-Severity (CGI-S) to measure remission and recovery rates, the Chinese version of the Social Adjustment Inventory for Children and Adolescents (CSAICA), and caregiver%26apos;s satisfaction rate, treatment adherence, and frequency of adverse effects. %26lt;br%26gt;Results: According to the SNAP-IV-C scores, the remission rate was 30.72%, and the recovery rate was 16.38%. Compared to short-acting IR-MPH, OROS-MPH was associated with greater functional improvement and treatment adherence among children with ADHD. %26lt;br%26gt;Conclusion: OROS-MPH treatment at the adequate dosage can achieve higher remission and recovery rates, produce greater functional improvement, and result in better treatment adherence than IR-MPH treatment.

• 出版日期2012-2
• 单位长春大学