UV-ABSORPTION MECHANISMS OF Ni2+-BINDING BOVINE SERUM ALBUMIN

作者：Dieaconu M; Ioanid A^*; Iftimie S; Antohe S

来源：Digest Journal of Nanomaterials and Biostructures, 2012, 7(3): 1125-1137.

• bovine serum albumin
• transition metal complex symmetry
• molecular orbital
• electronic transitions
• charge transfer transitions

Interactions proteins-metalic ions are a major concern in various emerging fields like bionanotchnology and material sciences. Nickel is known to be an essential element for the living organisms those deficiences cause allergic reactions, dermatitis, asthma, and also can induce carcinogenesis. Although it is known that binds to albumin, his physiological role is not complete established. Certainly, this role must be connected to the intimate physical and electrochemical features of the binding process. We present any new results concerning the binding process of Ni2+ on BSA, according to the UV absorbance spectrum structure of the [BSA:Ni2+][1:1] M system, with concentration (0.01 divided by 1) x 10(-4) M, in buffer phosphate solution having pH-value neighbouring the physiological values.

• 出版日期2012-9