Association of thalassemia major and gingival inflammation: A pilot study

作者：Gumus Pinar; Kahraman Ceneli Selda; Akcali Aliye; Sorsa Timo; Tervahartiala Taina; Buduneli Nurcan; Ozcaka Ozgun^*

来源：Archives of Oral Biology, 2016, 64: 80-84.

DOI：10.1016/j.archoralbio.2015.12.008

• Gingiva
• Inflammation
• Matrix metalloproteinase 8
• Matrix metalloproteinase 9
• Tissue inhibitor of metalloproteinase-1
• Thalassemia major

Objectives: This cross-sectional study aimed to investigate the relationship between thalassemia major (TM) and gingival inflammation through the salivary, serum, and gingival crevicular fluid (GCF) levels of matrix metalloproteinase (MMP)-8, MMP-9 and tissue inhibitor of MMP (TIMP)-1.
Methods: Biofluid samples and full-mouth clinical periodontal recordings were obtained from 29 otherwise healthy patients with TM and 25 systemically healthy (SH) individuals. Biofluid samples were evaluated by immunofluorometric assay (IFMA) and enzyme-linked immunoassays (ELISAs). Data were tested statistically by Kolmogorov Simirnov, Mann-Whitney Utests, Spearman correlation analysis.
Results: Age, smoking status, bleeding on probing, plaque index were similar in the study groups, but probing depth, gender data exhibited significant differences (p = 0.037 for both). Salivary MMP-8, MMP-9, TIMP-1 concentrations were significantly higher in the TM than SH group (p = 0.014; p < 0.001; p = 0.042, respectively). Serum TIMP-1 concentrations were significantly higher; MMP-8/TIMP-1, MMP-9/TIMP-1 molar ratios were significantly lower in the TM than SH group (p < 0.001; p = 0.005; p = 0.022, respectively). Very few GCF samples revealed biochemical data above the detection limits. Numerous correlations were found between clinical periodontal parameters and biochemical data.
Conclusions: It may be suggested that TM may exacerbate the local inflammatory response as manifested in salivary MMP-8, MMP-9, TIMP-1 levels.

• 出版日期2016-4