Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia

作者：Hermawan Idam; Furuta Atsushi; Higashi Masahiro; Fujita Yoshihisa; Akimitsu Nobuyoshi; Yamashita Atsuya; Moriishi Kohji; Tsuneda Satoshi; Tani Hidenori; Nakakoshi Masamichi; Tsubuki Masayoshi; Sekiguchi Yuji; Noda Naohiro^*; Tanaka Junichi^*

来源：Marine Drugs, 2017, 15(4): 117.

DOI：10.3390/md15040117

• hepatitis C virus (HCV)
• NS3 helicase
• crinoid
• aromatic sulfates

Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1-4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1-4 showed moderate inhibition against NS3 helicase with IC50 values of 71, 95, 7, and 5 mu M, respectively.

• 出版日期2017-4
• 单位河北医科大学