Adult neurogenesis in the four-striped mice (Rhabdomys pumilio)

作者：Olaleye Olatunbosun O; Ihunwo Amadi O^*

来源：Neural Regeneration Research, 2014, 9(21): 1907-1911.

DOI：10.4103/1673-5374.143435

• nerve regeneration
• adult neurogenesis
• four-striped mouse
• Ki-67
• doublecortin
• subventricular zone
• dentate gyrus
• olfactory bulb
• potential neurogenic site
• neural plasticity
• neural regeneration

In this study, we investigated non-captive four-striped mice (Rhabdomys pumilio) for evidence that adult neurogenesis occurs in the adult brain of animal models in natural environment. Ki-67 (a marker for cell proliferation) and doublecortin (a marker for immature neurons) immunostaining confirmed that adult neurogenesis occurs in the active sites of subventricular zone of the lateral ventricle with the migratory stream to the olfactory bulb, and the subgranular zone of the dentate gyrus of the hippocampus. No Ki-67 proliferating cells were observed in the striatum substantia nigra, amygdala, cerebral cortex or dorsal vagal complex. Doublecortin-immunoreactive cells were observed in the striatum, third ventricle, cerebral cortex, amygdala, olfactory bulb and along the rostral migratory stream but absent in the substantia nigra and dorsal vagal complex. The potential neurogenic sites in the four-striped mouse species could invariably lead to increased neural plasticity.

• 出版日期2014-11