A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community

作者：Muzembo Basilua Andre^*; Nagano Yasunori; Eitoku Masamitsu; Ngatu Nlandu Roger; Matsui Tomomi; Bhatti Sabah Asif; Hirota Ryoji; Ishida Kenji; Suganuma Narufumi

来源：Environmental Health and Preventive Medicine, 2014, 19(1): 21-29.

DOI：10.1007/s12199-013-0350-x

• Oxidative stress
• Handgrip strength
• Cross-sectional study
• Older persons
• Lifestyle

The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons.
This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength.
Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors.
Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.

• 出版日期2014-1